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What is ALS? · Sporadic. This is the most common form of ALS in the U.S., making up 90% to 95% of all cases. These cases occur randomly, without any known cause. ALS can be classified as either sporadic or familial. Most cases are sporadic. That means no specific cause is known. Familial ALS happens when the condition is. In approximately 10% of cases, ALS is directly caused by a genetic mistake, called mutation. Mutations can cause the cell to make either too little protein, or.

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What are the symptoms of ALS? · Twitching and cramping of muscles, especially those in the hands and feet · Loss of motor control in the hands and arms · Trouble. Early Symptoms and Diagnosis of ALS · twitching, cramping, or stiffness of muscles · muscle weakness causing trouble with walking or running · trouble writing. Still, for the majority of ALS cases – known as sporadic ALS – cause is unknown. Something genetic is almost certainly at work, if only for a predisposition to.

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The majority of ALS cases are sporadic (not inherited) and of unknown cause. Approximately 5–10 percent of cases are hereditary; roughly 30 percent of these. Possible causes of sporadic ALS · Oxidative stress · Mitochondrial dysfunction · Abnormalities of the immune system · Glutamate toxicity · Toxic exposures. Mutations in the SOD1 gene are found in percent of all ALS patients in the Nordic region. The genetic mutations cause the SOD1 protein to misfold, thereby.